Weill Cornell Bone Marrow Transplant Program

Allogeneic Transplantation for Patients With Advanced Myelofibrosis: Splenomegaly and High Serum LDH are Adverse Risk Factors for Successful Engraftment

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Myelofibrosis is an often aggressive form of myeloproliferative disease. Many patients benefit from medical therapy, but others are better served with a stem cell transplantation. Dr. Usama Gergis from our team recently reported the outcomes for 30 patients transplanted at our institution between 2000 and 2014. He showed that long term cure can be obtained, but that the risks are considerable, particularly in patients with massive splenomegaly.

http://www.sciencedirect.com/science/article/pii/S2152265016000598

These historical data are informative, but are unlikely to represent current outcomes.  Better supportive care and earlier referral have over the past years resulted in markedly improved outcomes.

 

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